Robert F DuBose

Title: The Innovative Contributions of Robert F DuBose

Introduction

Robert F DuBose is a notable inventor based in Bellevue, WA (US), recognized for his significant contributions to the field of biotechnology. With a total of 9 patents to his name, DuBose has made remarkable advancements in engineering cells for adoptive therapy.

Latest Patents

Among his latest patents is the invention of modified chimeric receptors and related compositions and methods. This invention provides chimeric receptors for engineering cells, including T cells, for adoptive therapy. The genetically engineered cells feature chimeric antigen receptors (CARs) that are modified in a junction region, resulting in a lower binding affinity for human leukocyte antigen (HLA) and reduced immunogenicity. Additionally, DuBose has developed methods and compositions for engineering and producing cells expressing these chimeric receptors, which enhance activity, efficacy, and persistence. Another significant patent involves viral encoded semaphorin protein receptor DNA and polypeptides, focusing on VESPR polypeptides as purified proteins and the methods for their preparation.

Career Highlights

DuBose has worked with prominent companies in the biotechnology sector, including Immunex Corporation and Juno Therapeutics GmbH. His work has contributed to the advancement of therapeutic techniques and has had a lasting impact on the industry.

Collaborations

Throughout his career, DuBose has collaborated with notable colleagues, including Melanie K Spriggs and Michael R Comeau. These partnerships have fostered innovation and have played a crucial role in the development of his patented technologies.

Conclusion

Robert F DuBose's innovative work in biotechnology, particularly in the field of cell engineering, has led to significant advancements that hold promise for future therapeutic applications. His contributions continue to influence the landscape of medical science and technology.