Immunex Corporation

Juno Therapeutics Gmbh

Robert F DuBose

Melanie K Spriggs

Michael R Comeau

Richard S Johnson

Steven R Wiley

Howard R G Clarke

Lucas James Thompson

Adel Youakim

Archana Brahmandam

Provided are chimeric receptors for engineering cells for adoptive therapy, including T cells, and the genetically engineered cells. In some embodiments, the chimeric receptors, such as chimeric antigen receptors (CARs) are modified in a junction region by one or more amino acid modifications such that peptide fragments of such region exhibit a lower binding affinity for a human leukocyte antigen (HLA) and/or the region exhibits reduced immunogenicity, including following administration to a subject. In some aspects, also provided are methods and compositions for engineering and producing cells expressing such chimeric receptors, compositions containing the cells, and method for their administration to subjects. In some embodiments, features of the chimeric receptors and engineered cells containing the chimeric receptors result in methods that provide for increased or improved activity, efficacy and/or persistence.

Modified chimeric receptors and related compositions and methods

The invention is directed to VESPR polypeptides as a purified and isolated protein, the DNA encoding the VESPR polypeptide, host cells transfected with cDNAs encoding VESPR, and methods for preparing VESPR polypeptides.

Viral encoded semaphorin protein receptor DNA and polypeptides

This invention relates to new members of the human Claudin polypeptide family, to methods of making such polypeptides, and to methods of using them to treat Claudin-associated conditions and to identify compounds that alter Claudin polypeptide activities.

Claudin polypeptides

This invention relates to Thypin, a new member of the human serpin polypeptide family, methods of making Thypin polypeptides and using these polypeptides to treat various medical disorders and to methods of screening for compounds that agonize or antagonize Thypin polypeptide activities.

Human serpin polypeptides

Antibodies to viral encoded semaphorin protein receptor polypeptides

Viral encoded semaphorin protein receptor polypeptides

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Bellevue, WA, United States of America

Robert F DuBose