Richard J Albertini

Title: Richard J Albertini: Innovator in Diabetes Research

Introduction

Richard J Albertini is a notable inventor based in Underhill Center, Vermont, who has made significant contributions to the field of diabetes research. With a total of three patents to his name, Albertini's work focuses on innovative methods to combat diabetes and enhance our understanding of immune responses.

Latest Patents

Albertini's latest patents include groundbreaking inventions aimed at addressing diabetes. One of his notable inventions involves peptides and methods against diabetes. This invention relates to methods of preventing or reducing the severity of diabetes. In one embodiment, the method involves administering to the individual a peptide having substantially the sequence of a non-conserved region sequence of a T cell receptor present on the surface of T cells mediating diabetes or a fragment thereof. The peptide or fragment is capable of causing an effect on the immune system to regulate the T cells. In particular, the T cell receptor has the V.beta. regional V.beta.6 or V.beta.14. Another embodiment of the method involves gene therapy. Additionally, the invention relates to methods of diagnosing diabetes by determining the presence of diabetes predominant T cell receptors.

Another significant patent by Albertini provides methods for identifying lymphocytes with a mutator phenotype. This invention offers methods for identifying lymphocytes by isolating those bearing a selectable marker. It involves identifying among the lymphocytes a population belonging to the same clonally amplified set and determining whether the population has at least two lymphocytes having, between them, two independent mutations among different alleles at the gene locus of the selectable marker. The presence of these mutations indicates a mutator phenotype, with the selectable marker being hprt.sup.- in one embodiment.

Career Highlights

Throughout his career, Richard J Albertini has worked with esteemed institutions, including the University of Vermont and The Immune Response Corporation. His work in these organizations has allowed him to advance his research and contribute to the scientific community.

Collaborations

Albertini has collaborated with various professionals in his field, including his coworker Michael T Falta. Their joint efforts have furthered the research and development of innovative solutions in diabetes treatment.

Conclusion

Richard J Albertini stands out as an influential inventor in the realm of diabetes research. His innovative patents and collaborations reflect his commitment to advancing medical science and improving patient outcomes.