The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 09, 1996
Filed:
Jan. 14, 1994
Applicant:
Inventor:
Richard J Albertini, Underhill Center, VT (US);
Assignee:
University of Vermont, Burlington, VT (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q / ; C12N / ;
U.S. Cl.
CPC ...
435-6 ; 435-724 ; 435 15 ; 435 29 ; 4351721 ;
Abstract
This invention provides methods for identifying lymphocytes with a mutator phenotype by isolating lymphocytes bearing a selectable marker; identifying among the lymphocytes a population belonging to the same clonally amplified set; and determining whether the population has at least two lymphocytes having, between them, two independent mutations among different alleles at the gene locus of the selectable marker; the presence of which indicates a mutator phenotype. In one embodiment of the invention, the selectable marker is hprt.sup.-.