Richard D Cramer

Title: The Innovative Contributions of Richard D Cramer

Introduction

Richard D Cramer is a notable inventor based in Santa Fe, NM (US), recognized for his significant contributions to the field of molecular alignment and drug discovery. With a total of 10 patents to his name, Cramer has developed innovative methodologies that enhance the understanding and application of three-dimensional quantitative structure-activity relationship (3D QSAR) analyses.

Latest Patents

Cramer's latest patents include a method for aligning molecules in three dimensions based on their correspondence to an exemplary template molecule. This computerized procedure allows for the alignment of molecules without relying on fragmentation, instead focusing on the comparison to identified template molecules. The process begins with identifying an anchor bond in both the candidate and template molecules, which have similar atoms at each end. The candidate molecule is then overlaid onto the template by aligning these anchor bonds. This method facilitates the identification of matching atoms or atom types, ultimately assigning the 3D coordinates of the template atoms to the corresponding atoms in the candidate molecule.

Another significant patent involves template-constrained fragment alignment, which identifies fragments of similar shape and activity in drug development. This computational drug discovery method enables users to specify a three-dimensional representation of a molecular fragment derived from a query molecule. This representation serves as a template for aligning fragments from database libraries, allowing for predictions regarding the likely activity of substitutions based on shape characterization and CoMFA analysis.

Career Highlights

Throughout his career, Richard D Cramer has worked with various companies, including Tripos, Inc. His work has significantly impacted the field of computational drug discovery, providing valuable tools for researchers and pharmaceutical companies.

Collaborations

Cramer has collaborated with notable individuals in his field, including Robert Jilek and David E Patterson. These collaborations have further enriched his research and contributions to molecular alignment and drug discovery.

Conclusion

Richard D Cramer stands out as an influential inventor whose work in molecular alignment and drug discovery has paved the way for advancements in the field. His innovative patents and collaborative efforts continue to inspire future research and development in the industry.