Richard Anthony Chizzonite

Title: Richard Anthony Chizzonite: Innovator in Cytokine Research

Introduction

Richard Anthony Chizzonite is a notable inventor based in South Kent, Connecticut, known for his significant contributions to the field of immunology. He holds five patents, showcasing his innovative work in the development of cytokine proteins and their applications in enhancing immune responses.

Latest Patents

One of Chizzonite's latest patents focuses on the purification and characterization of a novel cytokine protein known as IL-12, or Cytotoxic Lymphocyte Maturation Factor (CLMF). This protein is produced and synthesized by human NC-37 B lymphoblastoid cells. The invention highlights how CLMF synergistically induces the cytolytic activity of Lymphokine Activated Killer (LAK) cells when combined with low concentrations of IL-2. Additionally, CLMF is capable of stimulating T-cell growth. The patent also claims the cloned gene for CLMF, its recombination in a suitable vector, the transformed cells containing said vector, the recombinant protein produced by these cells, and antibodies to CLMF.

Career Highlights

Chizzonite's career is marked by his association with Hoffmann-La Roche Inc., where he has made significant strides in cytokine research. His work has contributed to advancements in understanding immune responses and developing therapeutic applications.

Collaborations

Chizzonite has collaborated with notable colleagues in his field, including Maurice Kent Gately and Ulrich Andreas Gubler. These collaborations have further enriched his research and innovation efforts.

Conclusion

Richard Anthony Chizzonite's contributions to cytokine research and his innovative patents underscore his role as a leading inventor in the field. His work continues to influence advancements in immunology and therapeutic development.