The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 07, 2012
Filed:
Oct. 08, 2002
Maurice Kent Gately, Montville, NJ (US);
Ulrich Andreas Gubler, Glen Ridge, NJ (US);
Jeffrey David Hulmes, Ringwood, NJ (US);
Frank John Podlaski, New City, NY (US);
Alvin Seth Stern, Passaic Park, NJ (US);
Richard Anthony Chizzonite, South Kent, CT (US);
Yu-ching Eugene Pan, Pine Brook, NJ (US);
Maurice Kent Gately, Montville, NJ (US);
Ulrich Andreas Gubler, Glen Ridge, NJ (US);
Jeffrey David Hulmes, Ringwood, NJ (US);
Frank John Podlaski, New City, NY (US);
Alvin Seth Stern, Passaic Park, NJ (US);
Richard Anthony Chizzonite, South Kent, CT (US);
Yu-Ching Eugene Pan, Pine Brook, NJ (US);
Hoffman-La Roche Inc., Nutley, NJ (US);
Abstract
The present invention is a novel cytokine protein called IL-12 or Cytotoxic Lymphocyte Maturation Factor (CLMF) which is produced and synthesized by human NC-37 B lymphoblastoid cells (American Type Culture Collection, Rockville, Md.). CLMF synergistically induces with low concentrations of IL-2 the cytolytic activity of Lymphokine Activated Killer (LAK) cells, and CLMF is capable of stimulating T-cell growth. Also claimed are the cloned gene for CLMF, its recombination in a suitable vector, the transformed cells containing said vector, the recombinant protein produced by the transformed cells and antibodies to CLMF.