Company Filing History:
1 out of 11 
2 out of 832,843 Years Active: 2009-2015
Title: Innovations of Randall L Kincaid
Introduction
Randall L Kincaid is a notable inventor based in Rockville, MD (US). He has made significant contributions to the field of neurotoxin research, particularly in identifying inhibitors of botulinum neurotoxins. With a total of three patents to his name, Kincaid's work has implications for both medical and scientific advancements.
Latest Patents
Kincaid's latest patents focus on methods for identifying inhibitors of botulinum neurotoxins. One patent describes a system and method for identifying a neurotoxin inhibitor using a substrate complex that includes a peptide substrate, preferably SNAP-25. This method involves a reporter domain and an immobilization domain on opposite sides of the peptide substrate. The effectiveness of the neurotoxin inhibitor is determined by its ability to reduce the amount of cleaved complex, which is measured by the decrease in complex bound to a solid support. Additionally, the invention includes novel cells that express a neurotoxin substrate complex and stable cell lines that can efficiently express an active light chain of the botulinum neurotoxin within mammalian cells.
Another patent elaborates on a similar system for identifying a botulinum neurotoxin inhibitor. This method also utilizes a botulinum neurotoxin substrate complex with a peptide substrate, SNAP-25, and aims to monitor the catalytic activity of the botulinum neurotoxin in living cells. The methods are designed for cell-based screening to identify molecules that inhibit the catalytic activity of the neurotoxin.
Career Highlights
Throughout his career, Kincaid has worked with various organizations, including Synaptic Research, LLC. His innovative approaches have contributed to advancements in understanding and combating the effects of botulinum neurotoxins.
Collaborations
Kincaid has collaborated with notable individuals in his field, including George A Oyler and Paul S Fishman. Their combined expertise has likely enhanced the impact of Kincaid's research and inventions.
Conclusion
Randall L Kincaid's work in identifying inhibitors of botulinum neurotoxins showcases his innovative spirit and dedication to scientific advancement. His patents reflect a commitment to improving health outcomes through research and development.