Randal J Kaufman

This inventor holds 20 USPTO granted patents and 7 published patent applications, plus 1 CIPO patent, primarily in Biopharmaceutical Development. Top assignees: Genetics Institute, Inc., Novartis Corporation, Chiron Corporation. Active years: 1987-1999.

IDiyas Innovation Intelligence. (2026). Inventor Profile: Randal J Kaufman. Retrieved from https://idiyas.com/inventor/randal-j-kaufman

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

USPTO Granted Patents = 20 (Patent Applications = 7)

% Patents Active = 100.0

CIPO Patents = 1 (Patent Applications = 1)

Average Co-Inventor Count = 2.1

ph-index = 15

Forward Citations = 1,209(Granted Patents)

Company Filing History:

16 out of 392

Genetics Institute, Inc.

where one patent can have more than one assignee

Years Active: 1987-1999

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Areas of Expertise:

GM-CSF

Procoagulant Proteins

Eucaryotic Expression Systems

Granulocyte Macrophage-Colony Stimulating Factor

Recombinant Proteins

High Yield Production

Genetically Engineered Cells

Vectors

DNA Encoding

Tissue Plasminogen Activator

Host Cells

Transformation Methods

20 patents (USPTO):Sort by Forward CitationsExplore Patents

1. 5986079 - Expression of pace in host cells and methods of use thereof (1999-11-16),

2. 5965425 - Expression of pace in host cells and methods of use thereof (1999-10-12),

3. 5942221 - Recombinant primate granulocyte macrophage-colony stimulating factor (1999-08-24),

4. 5908763 - DNA encoding GM-CSF and a method of producing GM-CSF protein (1999-06-01),

5. 5891429 - Recombinant human granulocyte-macrophage-colony stimulating factor (1999-04-06),

6. 5720952 - Method of treating myelo-suppression with GM-CSF (1998-02-24),

7. 5563045 - Chimeric procoagulant proteins (1996-10-08),

8. 5460950 - Expression of PACE in host cells and methods of use thereof (1995-10-24),

9. 5451521 - Procoagulant proteins (1995-09-19),

10. 5422260 - Human factor VIII:c muteins (1995-06-06),

11. 5250421 - Method for producing factor VIII:C-type proteins (1993-10-05),

12. 5238820 - Multiply-amplifiable vectors for high level expression of exogenuos DNA (1993-08-24),

13. 5198349 - Method for producing factor VIII:C and analogs (1993-03-30),

14. 5079159 - Method for making tissue plasminogen activator (1992-01-07),

15. 5004803 - Production of procoagulant proteins (1991-04-02),

Title: Randal J Kaufman: Innovator in Endopeptidase Production

Introduction

Randal J Kaufman, based in Boston, MA, is a notable inventor with a robust portfolio of 20 patents. His work primarily focuses on the expression of endopeptidases in host cells, contributing significantly to advancements in biochemistry and biotechnology.

Latest Patents

Among his latest patents, Kaufman has developed compositions and methods for endopeptidase production that enhance the processing efficiencies of heterologous precursor polypeptides into mature polypeptides. These methods are especially critical for proteins that require gamma-carboxylation for biological activity. The breakthrough utilizes recombinant PACE, a mammalian endopeptidase that specifically targets dibasic amino acid sites, further solidifying Kaufman's impact in the field.

Career Highlights

Kaufman has made significant strides in his career by working with leading organizations such as Genetics Institute, Inc. and Novartis Corporation. His contributions within these companies have been pivotal in advancing research and development in biopharmaceuticals.

Collaborations

Throughout his career, Kaufman has collaborated with esteemed colleagues including Steven C Clark and Gordon G Wong. These partnerships have enhanced his research initiatives and led to impactful innovations within the biotechnology sector.

Conclusion

Randal J Kaufman's inventive contributions, particularly in the domain of endopeptidase production, highlight his role as a significant figure in biotechnology. His extensive patent portfolio reflects his commitment to advancing scientific understanding and application in this crucial field.

Profile summary based on public USPTO records.