Randal D Goff

Title: Randal D Goff: Innovator in Glycosylation Research

Introduction

Randal D Goff is a prominent inventor based in Madison, WI (US). He has made significant contributions to the field of glycosylation, particularly in the development of neoglycosides and their applications in cancer and HIV research. With a total of 3 patents, Goff's work has the potential to impact therapeutic strategies in oncology and virology.

Latest Patents

Goff's latest patents include "Enhanced neoglycosides through neoglycosylation and methods of use thereof." This patent explores the effects of differential glycosylation on the anticancer and anti-HIV properties of the triterpenoid betulinic acid (BA). A library of 37 differentially glycosylated BA variants was tested, leading to the discovery of enhanced analogs with distinct antitumor and antiviral properties based on the appended sugar. Another notable patent is "Glycosylated chlorambucil analogs and uses thereof," which discloses a library of glycosylated chlorambucil analogs useful as anti-tumor and/or anti-metastatic agents.

Career Highlights

Goff is affiliated with the Wisconsin Alumni Research Foundation, where he continues to advance his research in glycosylation. His innovative work has garnered attention in the scientific community, contributing to the understanding of how glycosylation can influence drug efficacy.

Collaborations

Throughout his career, Goff has collaborated with notable colleagues, including Jon Scott Thorson and Albee Messing. These collaborations have further enriched his research and expanded the impact of his inventions.

Conclusion

Randal D Goff's contributions to glycosylation research exemplify the intersection of innovation and practical application in medicine. His patents reflect a commitment to advancing therapeutic options for cancer and viral infections.