Ramesh Kumar Dhandapani

Title: Ramesh Kumar Dhandapani: Innovator in Insect Gene Modulation

Introduction

Ramesh Kumar Dhandapani is a notable inventor based in Lexington, KY (US). He has made significant contributions to the field of biotechnology, particularly in the modulation of gene expression in insects. With a total of two patents to his name, Dhandapani's work focuses on innovative solutions for controlling mosquito populations.

Latest Patents

Dhandapani's latest patents include the development of polylysine:epigallocatechin-3-o-gallate and dsRNA polyplexes for the control of mosquitoes. This invention relates to a polyplex composition designed to modulate the expression of a gene-of-interest in insects. The composition comprises a crosslinker, a cation, and a molecule for initiating RNA interference (RNAi). Additionally, he has developed modified-RNA nanoparticles aimed at improving RNA interference efficiency in insects. This patent highlights the use of nanoformulations of double-stranded RNA (dsRNA) to limit nuclease degradation and enhance cellular uptake, thereby improving the delivery of dsRNA for effective RNAi.

Career Highlights

Dhandapani is affiliated with the University of Kentucky Research Foundation, where he conducts his research and development activities. His work is pivotal in advancing the understanding of gene modulation techniques that can be applied to pest control.

Collaborations

One of his notable collaborators is Subba Reddy Palli, with whom he has worked on various projects related to RNA interference and insect gene modulation.

Conclusion

Ramesh Kumar Dhandapani is a prominent figure in the field of biotechnology, with innovative patents that contribute to pest control strategies. His research continues to pave the way for advancements in gene modulation techniques.