Ramesh Kashi

Title: Ramesh Kashi: Innovator in Cancer Treatment

Introduction

Ramesh Kashi is a prominent inventor based in Warren, NJ, known for his significant contributions to the field of cancer treatment. With a total of six patents to his name, Kashi has focused on developing innovative solutions that enhance the efficacy of cancer therapies.

Latest Patents

Among his latest patents is the invention of stable formulations of programmed death receptor 1 (PD-1) antibodies and methods of use thereof. This invention relates to stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. The formulations comprise between 5-200 mg/mL of anti-PD-1 antibody, or its fragments. Additionally, Kashi has developed methods for treating various cancers using these stable formulations, which can be administered intravenously or subcutaneously. Another notable patent involves the production of crystals of anti-human PD-1 monoclonal antibodies. This patent provides methods for producing such crystals and their applications in cancer treatment. The invention includes pembrolizumab crystals and a method for producing them, which has been utilized to solve the three-dimensional structure of pembrolizumab to a resolution of 2.3 Å.

Career Highlights

Ramesh Kashi has worked with leading companies in the pharmaceutical industry, including Merck Sharp & Dohme Corporation and Agenus Inc. His work has significantly impacted the development of cancer therapies, showcasing his dedication to advancing medical science.

Collaborations

Kashi has collaborated with notable professionals in his field, including Sarita Mittal and Ashwin Basarkar. These collaborations have further enriched his research and development efforts.

Conclusion

Ramesh Kashi's innovative work in the field of cancer treatment through his patents and collaborations highlights his commitment to improving patient outcomes. His contributions continue to pave the way for advancements in cancer therapies.