The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 2021
Filed:
Feb. 22, 2016
Paul Reichert, Montville, NJ (US);
Winifred W. Prosise, Ramsey, NJ (US);
Giovanna Scapin, New York, NY (US);
Xiaoyu Yang, Basking Ridge, NJ (US);
Ramesh Kashi, Warren, NJ (US);
Corey Strickland, Martinsville, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Paul Reichert, Montville, NJ (US);
Winifred W. Prosise, Ramsey, NJ (US);
Giovanna Scapin, New York, NY (US);
Xiaoyu Yang, Basking Ridge, NJ (US);
Ramesh Kashi, Warren, NJ (US);
Corey Strickland, Martinsville, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
Crystals of pembrolizumab and structurally similar anti-PD-1 monoclonal antibodies are provided, as well as methods of producing such crystals, and uses of compositions comprising such antibody crystals, e.g. in treatment of cancers. The present invention satisfies these needs and more by providing pembrolizumab crystals and a method producing pembrolizumab crystals. One embodiment of the method of the invention produces crystals suitable for X-ray diffraction, and the inventors herein used such crystals to solve the three-dimensional structure of pembrolizumab to 2.3 A resolution.