Ramesh Chandra Malhotra

Title: Ramesh Chandra Malhotra: Innovator in Chemical Processes

Introduction

Ramesh Chandra Malhotra is a notable inventor based in Madhya Pradesh, India. He has made significant contributions to the field of chemistry, particularly in the development of innovative methods for synthesizing important compounds. With a total of 4 patents to his name, Malhotra's work has implications in various industries, including pharmaceuticals.

Latest Patents

One of his latest patents is a method for the preparation of fentanyl. This invention outlines a process that includes reacting 4-piperidone hydrochloride monohydrate with aniline in a reducing environment to produce 4-anilinopiperidine. The subsequent steps involve reacting this compound with phenethyl halide under reflux conditions in a highly alkaline medium, ultimately converting it to fentanyl through a reaction with propionyl chloride. The final product is isolated by solvent extraction and purified through crystallization from petroleum ether at a temperature ranging from 60-80°C.

Another significant patent is an eco-friendly process for the preparation of 2-Chlorobenzylidene-Malononitrile (CS). This improved method begins with creating a malononitrile suspension by adding a specific percentage of malononitrile to water while stirring. A catalyst is then introduced, followed by the condensation of the malononitrile suspension with 2-chlorobenzaldehyde. The reaction is carefully controlled to maintain a temperature below 50°C, and the final product is filtered and dried under water vacuum.

Career Highlights

Ramesh Chandra Malhotra has worked with esteemed organizations such as the Defence Research & Development Organisation and the Director General of Defence Research and Development Organisation. His experience in these institutions has allowed him to contribute to various research projects and innovations in chemical processes.

Collaborations

Throughout his career, Malhotra has collaborated with notable colleagues, including Kumaran Ganesan and Krishnamurthy Sekhar. These partnerships have fostered a collaborative environment that has led to advancements in their respective fields.

Conclusion

Ramesh Chandra Malhotra's contributions to chemical innovation are noteworthy, particularly in the synthesis of critical compounds. His patents reflect a commitment to advancing scientific knowledge and developing eco-friendly processes. His work continues to influence the