Defence Research Development Organisation

The Director General, Defence Research and Development Organisation

Ramesh Chandra Malhotra

Krishnamurthy Sekhar

Kumaran Ganesan

Pradeep Kumar Gupta

Shri Prakash

Balwant Singh Batra

Ambuja Pande

Asheesh Kumar Jain

Vinita Dubey

Laxmi Manral

Ambati Narasimha Rao

Kshitij Chandel

Natarajan Gopalan

Rajagopalan Vijayaraghavan

Murlidhar J Mendki

Brahma Dutt Parashar

The invention provides a method for the preparation of fentanyl comprising: (a) reacting 4-piperidone hydrochloride monohydrate with aniline in presence of reducing environment to produce 4-anilinopiperidine (4-AP), (b) reacting the 4-AP as obtained from step (a) with phenethyl halide under reflux conditions in highly alkaline medium to give 4-anilino-N-phenethylpiperidine, and (c) converting the 4-anilino-N-phenethylpiperidine to fentanyl by reacting with propionyl chloride in presence of halogenated hydrocarbons, then isolating fentanyl by solvent extraction and purifying by crystallization from petroleum ether at a temperature ranging from 60-80&#xb0; C.

Method for the preparation of fentanyl

An improved process for the preparation of 2-chlorobenzylidenemalononitrile (CS) comprising of the steps of: preparing malononitrile suspension by adding 5-20% (wt %) preferably 12-14% malononitrile to water while constantly stirring and then adding 0.05-0.5% (v/v) preferably 0.1-0% of a catalyst like piperidine, pyridine, 2-picoline, 3-picoline, 4-picoline or morpholine preferably piperidine piperidine with constant stirring at 20-30&#xb0; C.; condensing the malononitrile suspension prepared in step (a) with 2-chlorobenzaldehyde by adding 10-15% (w/v) preferably 25-30%, of 2-chlorobenzaldehyde cover a period at 30-45 minutes so that the temperature of the reaction mixture remains below 50&#xb0; C., constantly stirring for 20-40 minutes, then filtering the CS and drying it at 20-30&#xb0; C. under water vacuum for 3-5 hrs.

Eco-friendly process for the preparation of 2-Chlorobenzylidene-Malononitrile (CS)

A process for the preparation of n-heneicosane is disclosed. The process comprises (a) reacting 2,4-alkaneanedione with 1-bromooctadecane in absolute ethanol in the presence of 18-crown-6 as catalyst to produce 2-heneicosanone; and (b) reducing said 2-heneicosanone using hydrazine hydrate and potassium hydroxide in ethylene glycol to obtain n-heneicosane.

Process for the preparation of n-heneicosane

A process for the complete destruction of gelled sulphur mustard (SM), comprising the steps of: (a) dissolving gelled sulphur mustard (SM) in organic solvent such as 2-chloroethanol, methanol, methyl cellosolve or mixtures of these to obtain a clear mixture, (b) incinerating the clear gelled sulphur mustard solvent mixture obtained from step (a); (c) dissolving residual gelled SM obtained from step (c) into non-toxic products; (d) chemically converting dissolved SM obtained from step (c) into non-toxic products.

Process for destruction of gelled sulphur mustard

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Madhya Pradesh, India

Ramesh Chandra Malhotra