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Years Active: 2023-2025
Title: Rameen Beroukhim: Innovator in Cell Evolution and CRISPR Technologies
Introduction
Rameen Beroukhim is a prominent inventor based in Boston, MA (US). He has made significant contributions to the field of cellular biology and genetic engineering, holding a total of 3 patents. His work focuses on innovative methods for studying cell evolution and developing CRISPR-based therapeutics.
Latest Patents
Beroukhim's latest patents include groundbreaking methods and compositions for studying cell evolution. The first patent details methods for tagging cells of interest, tracking the evolution of these tagged cells, and recovering the original tagged cells for further study. This involves tagging cells with a DNA construct that encodes a barcode sequence, allowing for the recovery of barcoded cells using a reporter construct with CRISPR target sequences specific to the barcode of interest.
His second patent describes methods for the rational design of CRISPR-Cas system-based therapeutics. This involves screening various CRISPR-Cas systems by expressing them in a test cell population and modifying target sequences. The goal is to select CRISPR-Cas systems that do not trigger a DNA-damage response signature, thereby enhancing the safety and efficacy of CRISPR-based therapies.
Career Highlights
Rameen Beroukhim has worked with esteemed organizations such as the Broad Institute, Inc. and Dana-Farber Cancer Institute Inc. His experience in these institutions has allowed him to collaborate with leading experts in the field and contribute to cutting-edge research.
Collaborations
Throughout his career, Beroukhim has collaborated with notable colleagues, including Pratiti Bandopadhayay and Paul Blainey. These collaborations have further enriched his research and innovation in the field of cellular biology.
Conclusion
Rameen Beroukhim is a distinguished inventor whose work in cell evolution and CRISPR technologies has the potential to revolutionize genetic research and therapeutic applications. His innovative patents and collaborations highlight his commitment to advancing scientific knowledge and improving health outcomes.
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