Ramachandra Reddy

Title: The Innovative Contributions of Ramachandra Reddy

Introduction

Ramachandra Reddy is a notable inventor based in Radnor, PA (US). He has made significant contributions to the field of biotechnology, particularly in the development of synthetic Fab libraries for antibody discovery. His work has implications for therapeutic applications and enhances our understanding of antibody structure and function.

Latest Patents

Ramachandra Reddy holds one patent that describes combinatorial synthetic Fab libraries displayed on a phage pIX protein. The libraries were constructed using scaffolds that represent the most frequently used genes in human antibodies. These libraries were diversified to reflect the variability found in natural antibodies. After selection with a diverse panel of proteins, numerous specific and high-affinity Fabs were isolated. Through a process known as in-line maturation, the affinity of some antibodies was improved by up to one hundred-fold, resulting in low pM binders suitable for in vivo use. This patent demonstrates the feasibility of displaying complex Fab libraries as pIX-fusion proteins for antibody discovery and lays the groundwork for further studies on the structure-function relationship of antibodies.

Career Highlights

Ramachandra Reddy is currently employed at Janssen Biotech, Inc., where he continues to advance his research in biotechnology. His innovative work has positioned him as a key figure in the field, contributing to the development of new therapeutic strategies.

Collaborations

Throughout his career,