Company Filing History:
1 out of 2 Years Active: 2025
Title: Innovations of Raja Mukherjee in Peptide Libraries
Introduction
Raja Mukherjee is an accomplished inventor based in Edmonton, Canada. He has made significant contributions to the field of peptide libraries, focusing on genetically-encoded macrocyclic and bicyclic peptides. His innovative work has led to the development of methods that enhance the efficiency of peptide synthesis and screening.
Latest Patents
Raja Mukherjee holds two notable patents. The first patent is titled "Genetically-encoded macrocyclic peptide libraries bearing a pharmacophore." This invention relates to a method of forming a macrocyclic peptide that includes a pharmacophore. The process involves reacting a peptide with two thiol groups of cysteine side chains with the reactive compound 1,5-dichloropentanedion-2,4. The resulting macrocyclic polypeptide contains a 1,3-diketone group, which can be modified for use in libraries for biopanning against selected targets.
The second patent is "Genetically-encoded bicyclic peptide libraries." This invention describes a bicyclic peptide complex that includes a polypeptide with a free terminus and a twofold-symmetric linker compound. The linker is covalently attached to the polypeptide and at least two discrete side chains. This invention also encompasses methods for creating these complexes and screening them for various applications.
Career Highlights
Raja Mukherjee is currently employed at 48Hour Discovery Inc., where he continues to push the boundaries of peptide research. His work is instrumental in advancing the understanding and application of peptide libraries in drug discovery and development.
Collaborations
Raja collaborates with talented individuals in his field, including Ratmir Derda and Vivian Triana. Their combined expertise fosters an environment of innovation and creativity, leading to groundbreaking advancements in peptide technology.
Conclusion
Raja Mukherjee's contributions to the field of peptide libraries exemplify the spirit of innovation in scientific research. His patents reflect a commitment to enhancing methodologies that can significantly impact drug discovery.