Company Filing History:
4 out of 1,635 
2 out of 2 
1 out of 832,966 Years Active: 2010-2014
Title: The Innovations of Radu O Minea: Protein Expression Expert
Introduction
Radu O Minea, located in Arcadia, California, is a prominent inventor specializing in protein expression technologies. With a remarkable portfolio of five patents, Minea has significantly contributed to the field of biochemistry and molecular biology.
Latest Patents
His latest innovations include two notable patents focused on expressing proteins with disulfide bridges. The first patent, titled "Method of expressing proteins with disulfide bridges with enhanced yields and activity," outlines a more efficient natural selection process that generates increased amounts of correctly-folded active conformers of proteins, particularly Vicrostatin (VCN) and Contortrostatin (CN). This invention achieves enhanced protein production by growing Origami B cells in an optimal redox environment.
The second patent, simply titled "Method of expressing proteins with disulfide bridges," pertains to expressing eukaryotic proteins in prokaryotic hosts, especially those requiring disulfide bridges for their biological functions. This method utilizes various strategies, including fusion to thioredoxin and the cytoplasmic expression of disulfide isomerases, to produce active monomeric and dimeric forms of disintegrins. These innovations hold significant promise for biological applications, including therapeutic and research-related uses.
Career Highlights
Throughout his career, Radu O Minea has made notable contributions while working with esteemed organizations such as the University of Southern California and Pivotal Biosciences, Inc. His work at these institutions has furthered the development of innovative methods for protein expression, making a lasting impact in the field.
Collaborations
Collaboration plays a crucial role in Minea's research endeavors. He has worked alongside reputable scientists, including Francis S Markland, Jr and Stephen D Swenson, who have contributed to his pursuit of advancing protein expression methodologies.
Conclusion
Radu O Minea stands out as a leading inventor in the protein expression field, with his patented inventions paving the way for improved yield and activity of biologically important proteins. His dedication to innovation continues to inspire and drive advancements in biochemistry and molecular biology, contributing to scientific discoveries and medical advancements.