Rachel Louise Price

Title: Rachel Louise Price: Innovator in Recombinant Proteins

Introduction

Rachel Louise Price is a distinguished inventor based in Salisbury, GB. She has made significant contributions to the field of recombinant proteins, particularly in the development of mutant luciferases. With a total of 5 patents to her name, her work has garnered attention for its innovative applications in various assays.

Latest Patents

One of her latest patents is focused on a luciferase mutant, which is a recombinant protein exhibiting luciferase activity. This mutant shows at least 60% similarity to a wild-type luciferase. The invention involves a specific mutation at residue 357, changing an acidic amino acid to a non-acidic amino acid, preferably an uncharged polar amino acid like tyrosine. This alteration allows the luciferase enzyme to emit light at a different wavelength and enhances its thermostability. The mutant luciferases can produce a significant 50 nm wavelength shift in emitted light, which can be reversed by the addition of coenzyme A. These properties make her mutant particularly useful in a variety of assays.

Another notable patent involves an isolated recombinant luciferase that has an amino acid sequence differing from the wild-type luciferase. In this case, the amino acid residue corresponding to phenylalanine 295 or leucine 297 is mutated, resulting in increased thermostability compared to the wild-type luciferase.

Career Highlights

Throughout her career, Rachel has worked with prominent organizations, including Promega Corporation and the Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland. Her experience in these institutions has contributed to her expertise in the field of recombinant proteins.

Collaborations

Rachel has collaborated with notable colleagues such as David James Squirrell and Melenie Jane Murphy. These partnerships have further enriched her research and development efforts in the field.

Conclusion

Rachel Louise Price is a pioneering inventor whose work in recombinant proteins has led to significant advancements in the field. Her innovative patents and collaborations highlight her contributions to science and technology.