Location History:
- Southborough, MA (US) (2019 - 2021)
- Needham, MA (US) (2015 - 2023)
Company Filing History:
12 out of 1,206 
4 out of 1,370 
1 out of 2 Years Active: 2015-2025
Title: Innovations and Contributions of Inventor Quan Zhu
Introduction
Quan Zhu is a prominent inventor based in Needham, MA, known for his significant contributions to the field of biomedical research. With a total of 12 patents to his name, he has made remarkable advancements in the development of therapeutic antibodies and engineered cells.
Latest Patents
Among his latest patents is the invention of humanized CC chemokine receptor 4 (CCR4) antibodies and methods of use thereof. This invention provides humanized monoclonal antibodies, bi-specific antibodies, antibody conjugates, and fusion proteins that bind to the chemokine receptor CCR4. The antibody is derived from CCR4-IgG1 and recognizes the same epitope. It contains either an IgG4 or a stabilized IgG4 to improve binding efficiency and reduce in vivo Fab arm exchange. The binding of these antibodies to CCR4 inhibits ligand-mediated activities and is utilized in treating symptoms of cancer. Another notable patent is directed to engineered cells and methods for using the same. This invention involves engineered cells that comprise a nucleic acid encoding a chimeric antigen receptor and a polypeptide. The chimeric antigen receptor is specific for two or more antigens on the surface of a cancer cell, and the polypeptide includes an antibody or fragment that can be secreted from the engineered cell.
Career Highlights
Throughout his career, Quan Zhu has worked with esteemed institutions such as Dana-Farber Cancer Institute Inc. and Brigham and Women's Hospital, Inc. His work has significantly impacted cancer research and treatment methodologies.
Collaborations
Quan Zhu has collaborated with notable colleagues, including Wayne A. Marasco and De-Kuan Chang, contributing to various innovative projects in the field of cancer therapeutics.
Conclusion
In summary, Quan Zhu's innovative work in developing therapeutic antibodies and engineered cells has made a substantial impact on cancer treatment. His contributions continue to advance the field of biomedical research and improve patient outcomes.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.