The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 16, 2016
Filed:
Jan. 14, 2015
Applicants:
Dana-farber Cancer Institute, Inc., Boston, MA (US);
The Brigham and Women's Hospital, Boston, MA (US);
Inventors:
Wayne Marasco, Wellesley, MA (US);
Jianhua Sui, Waltham, MA (US);
Quan Zhu, Needham, MA (US);
Thomas Kupper, Belmont, MA (US);
Assignees:
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
The Brigham and Women's Hospital, Boston, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 14/715 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7158 (2013.01); C07K 16/2866 (2013.01); C07K 2316/96 (2013.01); C07K 2317/24 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/73 (2013.01); C07K 2317/732 (2013.01); C07K 2317/734 (2013.01); C07K 2317/74 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2319/30 (2013.01);
Abstract
The present invention comprises a humanized monoclonal antibody that binds to the chemokine receptor CCR4. This antibody is derived from Mab 1567 and recognizes the same epitope. Binding of the invented antibody to CCR4 inhibits ligand-mediated activities and is used to treat symptoms of cancer. Moreover, the antibody is used in combination with vaccines to suppress the activity of regulatory T cells.