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Title: Qiwei Lang: Innovator in Asymmetric Synthesis
Introduction
Qiwei Lang is a prominent inventor based in Shenzhen, China. He has made significant contributions to the field of asymmetric synthesis, particularly in the development of chiral ligands and methods for synthesizing complex molecules. With a total of 3 patents, his work has garnered attention in the scientific community.
Latest Patents
One of Qiwei Lang's latest patents is focused on a chiral multidentate ligand and its application in asymmetric hydrogenation. This patent discloses a method where compound (M1) undergoes condensation with compound (M2), followed by amine deprotection in the presence of a deprotection reagent to yield compound (M4). Additionally, compound (1) is deprotonated by butyl lithium and phosphorized, followed by dimethylamino group substitution to produce compound (3). The final step involves reacting compound (3) with compound (M4) in the presence of triethylamine to create chiral multidentate ligands. Another significant patent involves a method for asymmetrically synthesizing nicotine. This process includes a condensation reaction between nicotinic acid alkyl ester and N-methylpyrrolidone, followed by the addition of a strong acid to obtain 4-methylamino-1-(3-pyridine)-butanone hydrochloride. The intermediate is then reacted with an amino-protecting reagent to yield an intermediate (4), which is further processed to obtain a chiral alcohol (5) through asymmetric reduction. Finally, the chiral alcohol is converted into nicotine through a two-step reaction.
Career Highlights
Qiwei Lang has worked with notable companies such as Shenzhen Catalys Technology Co., Ltd. and Shenzhen Innovation Center of Small Molecule Drug Discovery Co., Ltd. His expertise in asymmetric synthesis has positioned him as a valuable asset in the pharmaceutical and chemical industries.
Collaborations
Throughout his career, Qiwei Lang has collaborated with esteemed colleagues, including Xiaobing Ding and Shaobai Yan. These partnerships have contributed to the advancement of innovative methodologies in drug discovery and synthesis.
Conclusion
Qiwei Lang's contributions to the field of asymmetric synthesis and his innovative patents highlight his role as a leading inventor in the industry. His work continues to influence advancements in chemical synthesis