This inventor holds 1 USPTO granted patent and 1 published patent application. Top assignee: Arrowhead Pharmaceuticals, Inc.. Active years: 2025.
Company Filing History:
Years Active: 2025
Title: Puhui Li: Innovator in RNAi Therapeutics
Introduction
Puhui Li is a prominent inventor based in San Diego, CA, known for his contributions to the field of RNA interference (RNAi) therapeutics. With a focus on innovative solutions for gene expression modulation, he has made significant strides in developing pharmaceutical compositions that target specific genes.
Latest Patents
Puhui Li holds a patent for "RNAi agents for inhibiting expression of inhibin subunit beta E (INHBE), pharmaceutical compositions thereof, and methods of use." This patent describes RNAi agents, particularly double-stranded RNAi agents such as small interfering RNAs (siRNAs), that effectively inhibit the expression of the INHBE gene. The disclosed pharmaceutical compositions include these RNAi agents and methods for their application. Notably, the INHBE RNAi agents can be conjugated to targeting ligands to enhance delivery to cells, including hepatocytes. The in vivo delivery of these agents offers a promising approach to inhibit INHBE gene expression, which is relevant in treating diseases associated with obesity, diabetes, liver inflammation, dyslipidemia, and metabolic disorders.
Career Highlights
Puhui Li is currently associated with Arrowhead Pharmaceuticals, Inc., where he continues to advance his research in RNAi technologies. His work is pivotal in the development of novel therapeutic strategies aimed at addressing complex metabolic diseases.
Collaborations
Puhui collaborates with esteemed colleagues, including Michelle Ngai and Feng Liu, who contribute to the innovative research environment at Arrowhead Pharmaceuticals.
Conclusion
Puhui Li's work in RNAi therapeutics exemplifies the potential of innovative approaches to gene expression modulation. His contributions are paving the way for new treatments for various metabolic diseases, showcasing the importance of research and development in the pharmaceutical industry.