The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 23, 2025
Filed:
Aug. 29, 2024
Arrowhead Pharmaceuticals, Inc., Pasadena, CA (US);
Michelle Ngai, Fitchburg, WI (US);
Feng Liu, Valley Center, CA (US);
Puhui Li, San Diego, CA (US);
Xiaokai Li, San Diego, CA (US);
Zhi-Ming Ding, Waunakee, WI (US);
Tao Pei, Middleton, WI (US);
Daniel Braas, Madison, WI (US);
So Wong, Oregon, WI (US);
James C. Hamilton, Sierra Madre, CA (US);
Grigoriy Shekhtman, Los Angeles, CA (US);
Arrowhead Pharmaceuticals, Inc., Pasadena, CA (US);
Abstract
The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents such as siRNAs, able to Inhibin Subunit Beta E (INHBE) gene expression. Also disclosed are pharmaceutical compositions that include INHBE RNAi agents and methods of use thereof. The INHBE RNAi agents disclosed herein may be conjugated to targeting ligands to facilitate the delivery to cells, including to hepatocytes. Delivery of the INHBE RNAi agents in vivo provides for inhibition of INHBE gene expression. The RNAi agents can be used in methods of treatment of diseases, disorders, or symptoms mediated in part by INHBE gene expression, such as obesity, diabetes, liver inflammation, dyslipidemia, or metabolic disease.