Priscilla Branchu

Title: Priscilla Branchu: Innovator in Gastrointestinal Treatments

Introduction

Priscilla Branchu is a notable inventor based in Toulouse, France. She has made significant contributions to the field of gastrointestinal health through her innovative research and inventions. Her work focuses on the probiotic properties of the modified strain Nissle 1917, which has implications for treating gastrointestinal disorders.

Latest Patents

Priscilla Branchu holds a patent for her invention titled "Modified strain Nissle and treatment of gastrointestinal disorder." This invention explores the mechanisms behind the probiotic properties of the strain Nissle 1917 (EcN). The research demonstrates how the ClbP protein, which activates the genotoxin colibactin, can be decoupled from its probiotic activity. The findings indicate that a modified strain of EcN, which has an inactive ClbP protein for the peptidase domain, is non-genotoxic while retaining its bacterial antagonist activity. This advancement paves the way for the safe use of EcN in treating gastrointestinal diseases.

Career Highlights

Throughout her career, Priscilla Branchu has worked with esteemed institutions such as the Institut National de la Santé et de la Recherche Médicale and Université Paul Sabatier Toulouse III. Her research has been pivotal in understanding the balance between probiotic benefits and potential genotoxicity in bacterial strains.

Collaborations

Priscilla has collaborated with notable colleagues, including Eric Oswald and Jean-Philippe Nougayrede. Their combined expertise has contributed to the advancement of research in the field of probiotics and gastrointestinal health.

Conclusion

Priscilla Branchu's innovative work in the field of modified strains for gastrointestinal treatment highlights her commitment to advancing health solutions. Her research not only enhances our understanding of probiotics but also opens new avenues for safe therapeutic applications.