Pinakpani Chakrabarti

Title: Innovations by Pinakpani Chakrabarti

Introduction

Pinakpani Chakrabarti is a notable inventor based in Kolkata, India. He has made significant contributions to the field of biochemistry, particularly in the study of chaperone proteins. His work focuses on developing therapeutic strategies that target specific proteins involved in cellular processes.

Latest Patents

Chakrabarti holds a patent for a process to identify peptide antagonists of Hsp16.3, a chaperone protein essential for survival in the dormant phase. The patent describes the affinity selection of 7-mer and 12-mer random peptide libraries displayed on bacteriophage M13, using recombinant Hsp16.3 as a template. Two peptide phage clones that bind to the Hsp16.3 protein were identified. Synthetic peptides corresponding to the sequences displayed on these phage clones were shown to specifically bind and inhibit the chaperone function of Hsp16.3 in vitro in a dose-dependent manner. The inhibitory effect of these peptides on the chaperone activity of alphaB-crystallin, a component of the human eye lens and a homologue of Hsp16.3, was found to be substantially less. These peptide inhibitors can serve as lead compounds for developing better therapeutics against latent conditions.

Career Highlights

Chakrabarti is affiliated with the Council of Scientific and Industrial Research, where he conducts his research. His work has garnered attention for its potential applications in medical science, particularly in the development of new therapeutic agents.

Collaborations

Chakrabarti has collaborated with notable colleagues, including Sujoy K Das Gupta and Abhik Saha. Their combined expertise has contributed to advancing research in the field of protein interactions and therapeutic development.

Conclusion

Pinakpani Chakrabarti's innovative work in identifying peptide antagonists of Hsp16.3 highlights the importance of targeted therapies in modern medicine. His contributions continue to pave the way for advancements in biochemistry and therapeutic strategies.