The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 2009
Filed:
May. 26, 2004
Sujoy K. Das Gupta, Kolkata, IN;
Abhik Saha, Kolkata, IN;
Archna Pathak Sharma, Kolkata, IN;
Siddhartha Roy, Kolkata, IN;
Bhabatarak Bhattacharya, Kolkata, IN;
Pinakpani Chakrabarti, Kolkata, IN;
Sujoy K. Das Gupta, Kolkata, IN;
Abhik Saha, Kolkata, IN;
Archna Pathak Sharma, Kolkata, IN;
Siddhartha Roy, Kolkata, IN;
Bhabatarak Bhattacharya, Kolkata, IN;
Pinakpani Chakrabarti, Kolkata, IN;
Abstract
A process to identify peptide antagonists of Hsp16.3, a chaperon protein necessary for the survival ofin the dormant phase is described. Affinity selection of a 7-mer and a 12-mer random peptide libraries displayed on bacteriophage M13 was performed using recombinant Hsp16.3 as template and two peptide phage clones, which bind to the Hsp16.3 protein were identified. Synthetic peptides corresponding to the peptide sequences displayed on these phage clones were able to specifically bind and inhibit the chaperone function of Hsp16.3 in vitro in a dose dependent manner. The corresponding inhibitory effect of these peptides on the chaperon activity of alphaB-crystallin, a constituent of human eye lens and a homologue of Hsp16.3, was found to be substantially less. These peptide inhibitors, or similar inhibitors generated by the process described, which specifically target Hsp16.3, can hence be used as lead compounds to obtain better therapeutics against latent