Archna Pathak Sharma

Title: Archna Pathak Sharma: Innovator in Peptide Antagonists

Introduction

Archna Pathak Sharma is a notable inventor based in Kolkata, India. She has made significant contributions to the field of biochemistry, particularly in the development of peptide antagonists. Her work focuses on understanding the chaperone protein Hsp16.3, which plays a crucial role in cellular survival during dormant phases.

Latest Patents

Archna holds a patent for a process to identify peptide antagonists of Hsp16.3. This patent describes a method involving affinity selection of 7-mer and 12-mer random peptide libraries displayed on bacteriophage M13. Using recombinant Hsp16.3 as a template, two peptide phage clones that bind to the Hsp16.3 protein were identified. The synthetic peptides corresponding to these sequences were shown to specifically bind and inhibit the chaperone function of Hsp16.3 in vitro in a dose-dependent manner. Notably, the inhibitory effect of these peptides on the chaperone activity of alphaB-crystallin, a component of the human eye lens and a homologue of Hsp16.3, was found to be substantially less. These peptide inhibitors can serve as lead compounds for developing better therapeutics against latent conditions.

Career Highlights

Archna is affiliated with the Council of Scientific and Industrial Research, where she continues her research and innovation. Her work has garnered attention for its potential applications in therapeutic development.

Collaborations

Some of her notable coworkers include Sujoy K Das Gupta and Abhik Saha, who have collaborated with her on various research projects.

Conclusion

Archna Pathak Sharma is a pioneering inventor whose work on peptide antagonists has the potential to lead to significant advancements in therapeutic strategies. Her contributions to the field of biochemistry are noteworthy and continue to inspire future research.