This inventor holds 2 USPTO granted patents. Top assignee: Cangene Corporation. Active years: 1999-2000.
Location History:
- Bolton, CA (1999)
- Brampton, CA (2000)
Company Filing History:
Years Active: 1999-2000
Title: Phyllis Krygsman: Innovator in Protein Expression Technologies
Introduction
Phyllis Krygsman is a notable inventor based in Brampton, Canada. She has made significant contributions to the field of protein expression, particularly in bacterial host cells. With a total of 2 patents, her work has advanced the understanding and application of protease inhibitors in biotechnology.
Latest Patents
Krygsman's latest patents include a method for the expression of proteins in bacterial host cells. This method utilizes an aminopeptidase inhibitor to enhance the expression of heterologous proteins in bacterial hosts, such as Streptomyces. The inhibitor plays a crucial role in preventing the degradation of these proteins by aminopeptidases. Additionally, she has developed methods to improve the secretion of proteins by addressing the degradation caused by a family of proteases endemic to Streptomyces cells. These proteases, including tripeptidyl aminopeptidase and others, can significantly impact the yield of secreted proteins. By selectively inhibiting these proteases or using hosts with reduced protease production capabilities, Krygsman has paved the way for more efficient protein expression.
Career Highlights
Krygsman is currently associated with Cangene Corporation, where she continues to innovate in the field of biotechnology. Her work has not only contributed to academic knowledge but has also had practical applications in various industries.
Collaborations
Throughout her career, Krygsman has collaborated with esteemed colleagues, including Michael J Butler and Timothy J Krieger. These partnerships have further enriched her research and development efforts.
Conclusion
Phyllis Krygsman's contributions to protein expression technologies highlight her role as a leading inventor in the field. Her innovative approaches and collaborative spirit continue to influence advancements in biotechnology.