Company Filing History:
Years Active: 2008
Title: **Inventor Profile: Philip J. Kingsley**
Introduction
Philip J. Kingsley, an accomplished inventor based in Nashville, TN, has made significant contributions to the field of enzymatic activity detection. His innovative approach focuses on the detection and quantification of COX-2 enzyme activity, which plays a crucial role in various biological processes and diseases.
Latest Patents
Philip J. Kingsley holds a patent titled "Compositions and methods for detecting and quantifying COX-2 activity by lipoamino acid metabolism." This groundbreaking invention involves a method to detect the activity of the COX-2 enzyme in a subject. The process includes obtaining a sample from the subject and detecting an amino acid eicosanoid metabolite in that sample. The presence of this metabolite indicates the COX-2 enzyme's activity. Notably, the metabolites targeted by this method include PGH-Gly and HETE-Gly, which can be detected through the metabolism of a COX-2-selective substrate, specifically a lipoamino acid such as NAGly, N-arachidonyl-alanine, or δ-arachidonyl aminobutyric acid.
Career Highlights
Kingsley is affiliated with Vanderbilt University, an institution renowned for its research and innovation. His work has expanded the understanding of COX-2 enzyme activity, linking it to various physiological and pathological processes. This advancement holds potential implications for developing therapeutic strategies for diseases associated with COX-2.
Collaborations
Working alongside esteemed colleagues such as Lawrence J. Marnett and Jeffery J. Prusakiewicz, Kingsley has been part of a team dedicated to pioneering research that combines biology and chemistry to address healthcare challenges. Their collaborative efforts have enhanced the scope of research in enzymatic activity detection.
Conclusion
Philip J. Kingsley's contributions to the field of enzyme activity detection exemplify the innovative spirit of inventors dedicated to improving health outcomes. His patent not only showcases his expertise but also sets a foundation for future research and developments in medical diagnostics. Through his work at Vanderbilt University and collaborations with other prominent researchers, Kingsley continues to impact the scientific community significantly.