The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2008
Filed:
Aug. 06, 2002
Lawrence J. Marnett, Nashville, TN (US);
Jeffery J. Prusakiewicz, Nashville, TN (US);
Kevin R. Kozak, Nashville, TN (US);
Philip J. Kingsley, Nashville, TN (US);
Lawrence J. Marnett, Nashville, TN (US);
Jeffery J. Prusakiewicz, Nashville, TN (US);
Kevin R. Kozak, Nashville, TN (US);
Philip J. Kingsley, Nashville, TN (US);
Vanderbilt University, Nashville, TN (US);
Abstract
A method of detecting an activity of a COX-2 enzyme in a subject that includes obtaining a sample of the subject; detecting an amino acid eicosanoid metabolite in the sample, wherein the presence of the amino acid eicosanoid metabolite indicates the activity of the COX-2 enzyme of the subject. Preferably the amino acid eicosanoid metabolite is a PGH-Gly or HETE-Gly metabolite. The metabolite may be detected based on metabolism of a COX-2-selective substrate. Preferably, the substrate is a lipoamino acid. More preferably, the lipoamino acid is selected from NAGly, N-arachidonyl-alanine, and δ-arachidonyl aminobutuyic acid.