Location History:
- Nashville, TN (US) (2007 - 2008)
- Quincy, MA (US) (2009)
Company Filing History:
Years Active: 2007-2009
Title: Kevin R Kozak: Innovator in COX-2 Activity Detection
Introduction
Kevin R Kozak is a prominent inventor based in Nashville, TN (US). He has made significant contributions to the field of biochemistry, particularly in the detection and quantification of COX-2 activity. With a total of three patents to his name, Kozak's work has implications for understanding inflammation and cancer.
Latest Patents
Kozak's latest patents include innovative methods and compositions for detecting and quantifying COX-2 activity. One of his notable inventions provides methods, compositions, and kits for discriminating between COX-1 and COX-2 activity. This invention allows for the detection and measurement of COX-2 activity in various subjects and samples. It highlights that 2-arachidonylglycerol is a COX-2 selective substrate, which is metabolized by COX-2 to produce prostaglandin glycerol esters (PG-Gs). The invention also introduces novel COX-2 selective metabolites, including prostaglandin I-glycerol ester (PGI-G) and 6-keto-prostaglandin F-glycerol ester. These methods and kits are essential for monitoring inflammation, tumors, and cancer, as well as for screening COX-2 specific inhibitors.
Another significant patent focuses on detecting COX-2 enzyme activity through lipoamino acid metabolism. This method involves obtaining a sample from a subject and detecting an amino acid eicosanoid metabolite, which indicates the activity of the COX-2 enzyme. The detection is based on the metabolism of a COX-2-selective substrate, specifically a lipoamino acid.
Career Highlights
Kevin R Kozak is affiliated with Vanderbilt University, where he continues to advance research in his field. His work has garnered attention for its potential applications in medical diagnostics and therapeutic development.
Collaborations
Kozak has collaborated with notable colleagues, including Lawrence J Marnett and Jeffery J Prusakiewicz. These collaborations have further enriched his research and contributed to the advancement of knowledge in COX-2 activity detection.
Conclusion
Kevin R Kozak is a distinguished inventor whose work in detecting COX-2 activity has significant implications for medical research and diagnostics. His innovative patents and collaborations reflect his commitment to advancing the