Philip D Compton

Title: The Innovations of Philip D Compton

Introduction

Philip D Compton is a notable inventor based in Charlottesville, VA (US). He has made significant contributions to the field of mass spectrometry, holding 2 patents that enhance the capabilities of this analytical technique. His work focuses on improving the efficiency and effectiveness of mass spectrometric analysis, particularly in the sequencing of peptides and proteins.

Latest Patents

One of his latest patents is titled "Reagents for electron transfer dissociation in mass spectrometry analysis." This invention provides improvements in reagents used in electron transfer dissociation ionization techniques for mass spectrometry. It particularly aids in sequencing peptides and proteins through electrospray ionization and MS/MS characterization of fragment ions. The novel reagents allow for a more effective determination of protein sequences, especially for long peptides or post-translationally modified protein fragments. The patent describes the use of polycyclic aromatic hydrocarbons such as azulene, homoazulene, and acenaphthylene, along with their homodimers and heterodimers.

Another significant patent is the "Method and apparatus for generation of reagent ions in a mass spectrometer." This patent discloses a front-end reagent ion source for a mass spectrometer. In this invention, reagent vapor is supplied to a reagent ionization volume within the mass spectrometer, maintained at low vacuum pressure. Reagent ions are formed through the interaction of reagent vapor molecules with an electrical discharge within the ionization volume. These ions are then transported to successive chambers of the mass spectrometer, where they can be combined with analyte ions for ion-ion studies, such as electron transfer dissociation (ETD).

Career Highlights

Philip D Compton has had a distinguished career, working with reputable institutions such as the University of Virginia and Thermo Finnigan LLC. His expertise in mass spectrometry has positioned him as a key figure in the development of innovative analytical techniques.

Collaborations

Throughout his career, Compton has collaborated with esteemed colleagues, including Donald F Hunt and Jeffrey Shabanowitz. These collaborations have further enriched his contributions to the field of mass spectrometry.

Conclusion

Philip D Compton's innovative work in mass spectrometry has led to significant advancements in the analysis of peptides and proteins. His patents reflect a deep understanding of the complexities of mass spectrometric techniques