Paula Irene Lario

This inventor holds 15 USPTO granted patents and 8 published patent applications, plus 8 CIPO patents and 6 EPO patents. Top assignees: Zymeworks Inc., Zymeworks Bc Inc.. Active years: 2016-2025.

IDiyas Innovation Intelligence. (2026). Inventor Profile: Paula Irene Lario. Retrieved from https://idiyas.com/inventor/paula-irene-lario

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

USPTO Granted Patents = 15 (Patent Applications = 8)

% Patents Active = 93.3

CIPO Patents = 8 (Patent Applications = 5)

EPO Patents = 6 (Patent Applications = 5)

Average Co-Inventor Count = 6.2

ph-index = 7

Forward Citations = 157(Granted Patents)

Company Filing History:

Years Active: 2016-2025

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15 patents (USPTO):Sort by Forward CitationsExplore Patents

1. 12304945 - Engineered immunoglobulin heavy chain-light chain pairs and uses thereof (2025-05-20),

2. 12060436 - Engineered immunoglobulin heavy chain-light chain pairs and uses thereof (2024-08-13),

3. 11286293 - Engineered immunoglobulin heavy chain-light chain pairs and uses thereof (2022-03-29),

4. 11152081 - Methods for determining correlated residues in a protein or other biopolymer using molecular dynamics (2021-10-19),

5. 11078296 - Engineered immunoglobulin heavy chain-light chain pairs and uses thereof (2021-08-03),

6. 10875931 - Stable heterodimeric antibody design with mutations in the Fc domain (2020-12-29),

7. 10457742 - Stable heterodimeric antibody design with mutations in the Fc domain (2019-10-29),

8. 10077298 - Engineered immunoglobulin heavy chain-light chain pairs and uses thereof (2018-09-18),

9. 9988460 - Crystal structures of heterodimeric Fc domains (2018-06-05),

10. 9914785 - Engineered immunoglobulin heavy chain-light chain pairs and uses thereof (2018-03-13),

11. 9732155 - Crystal structures of heterodimeric Fc domains (2017-08-15),

12. 9574010 - Stable heterodimeric antibody design with mutations in the Fc domain (2017-02-21),

13. 9562109 - Stable heterodimeric antibody design with mutations in the Fc domain (2017-02-07),

14. 9404928 - Methods for determining correlated residues in a protein or other biopolymer using molecular dynamics (2016-08-02),

15. 9296815 - Antibodies with enhanced or suppressed effector function (2016-03-29),

Title: **Innovative Contributions of Paula Irene Lario in Immunology**

Introduction

Paula Irene Lario is a prominent inventor based in Vancouver, Canada, known for her groundbreaking work in immunology. She holds an impressive portfolio of 14 patents, demonstrating her innovative contributions to the field. Her inventions primarily focus on engineered immunoglobulin heavy chain-light chain pairs, which have significant applications in therapeutic development.

Latest Patents

Lario's latest patents detail the design of heterodimer pairs that consist of engineered immunoglobulin heavy chains and light chains. These pairs are specifically designed to allow preferential pairing between light chains and heavy chains through strategic amino acid modifications. The unique structure enhances the efficiency of antibody production in mammalian cells, which can lead to better-targeted therapies. Her inventions represent a significant advancement in the generation of specialized antibodies for medical use.

Career Highlights

Throughout her career, Paula Lario has made noteworthy contributions while working with prominent companies, including Zymeworks Inc. and Zymeworks BC Inc. Her expertise and dedication have led to significant advancements in the understanding of antibody engineering, positioning her as a leader in the field.

Collaborations

Lario has collaborated with several esteemed professionals, including Surjit Bhimarao Dixit and Thomas Spreter Von Kreudenstein. These collaborations have fostered an environment of innovation, allowing for the exchange of ideas and methodologies that enhance research outcomes.

Conclusion

Paula Irene Lario's innovative spirit and dedication to advancing immunology through her patented inventions continue to make a lasting impact on the scientific community. Her work exemplifies the crucial role of inventors in developing new technologies that can transform healthcare and improve patient outcomes.

Profile summary based on public USPTO records.