Paul W J J Burgman

Title: Paul W J J Burgman: Innovator in Cancer Research

Introduction

Paul W J J Burgman is a notable inventor based in Astoria, NY (US). He has made significant contributions to the field of cancer research, particularly through his innovative approaches to enhancing the susceptibility of cells to DNA-damaging agents. With a total of 2 patents, his work is paving the way for new treatment methodologies.

Latest Patents

Burgman's latest patents focus on the uses of DNA-PK. The first patent provides methods for increasing the susceptibility of cells to DNA-damaging agents and for treating tumors in a subject. This involves introducing antisense that prevents the expression of DNA dependent protein kinase catalytic subunit Ku70 or Ku80. The antisense is administered in an amount sufficient to increase the sensitivity of the cells and tumors to heat, chemical, or radiation-induced DNA damage.

The second patent also addresses the method for increasing the susceptibility of a cell to DNA-damaging agents. This method comprises introducing an antisense oligonucleotide that specifically hybridizes to a nucleic acid encoding a DNA dependent protein kinase subunit. This action prevents the expression of the DNA dependent protein kinase subunit, thereby increasing the sensitivity of the cell to various forms of DNA damage. Additionally, this invention provides a method of treating a tumor in a subject by administering an antisense oligonucleotide that specifically hybridizes to a nucleic acid encoding a DNA dependent protein kinase subunit.

Career Highlights

Burgman is affiliated with the Sloan-Kettering Institute for Cancer Research, where he continues to advance his research and innovations. His work is crucial in the ongoing battle against cancer, as it explores new avenues for treatment and enhances the effectiveness of existing therapies.

Collaborations

One of his notable collaborators is Gloria C Li, with whom he has worked closely on various projects related to cancer research.

Conclusion

Paul W J J Burgman is a distinguished inventor whose work in cancer research is making a significant impact. His innovative patents are contributing to the development of more effective treatments for tumors, showcasing the importance of research and innovation in the medical field.