The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2010
Filed:
Dec. 28, 2000
Applicants:
Gloria C. LI, New York, NY (US);
Paul W. J. J. Burgman, Astoria, NY (US);
Inventors:
Gloria C. Li, New York, NY (US);
Paul W. J. J. Burgman, Astoria, NY (US);
Assignee:
Sloan-Kettering Institute for Cancer Research, New York, NY (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/04 (2006.01); C12Q 1/68 (2006.01); C12P 19/34 (2006.01); C12N 15/58 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract
This invention provides methods for increasing the susceptibility of cells to DNA-damaging agents, and for treating tumors in a subject, comprising introducing antisense that prevent expression of DNA dependent protein kinase catalytic subunit Ku70 or Ku80, wherein the antisense is in an amount sufficient to increase the sensitivity of the cells and tumors to heat, chemical, or radiation-induced DNA damage.