Paul R Brakeman

Title: Paul R Brakeman: Innovator in Synaptic Activation Proteins

Introduction

Paul R Brakeman is a notable inventor based in Baltimore, MD (US). He has made significant contributions to the field of neuroscience through his innovative work on synaptic activation proteins. With a total of 6 patents, Brakeman's research has implications for understanding neuronal activity and its effects on the central nervous system.

Latest Patents

Brakeman's latest patents include groundbreaking discoveries in the area of synaptic activation protein compositions and methods. One of his patents discloses nucleotide coding sequences and polypeptide sequences for synaptic activation binding proteins that are induced in the central nervous system following neuronal activity in the rat hippocampus. These proteins are characterized by substantial homology to defined rat, human, or mouse coding sequences or proteins. They also exhibit the ability to bind to and affect the activity of effector proteins in the CNS, such as metabotropic glutamate receptors. Additionally, the invention provides nucleotides and polypeptides useful in screening and diagnostic assays.

Another significant patent involves a method for identifying compounds that modulate cellular responses associated with Homer proteins. This includes methods for identifying compounds that inhibit Homer protein activity based on the crystal structure coordinates of the Homer protein binding domain. The invention also encompasses nucleic acids encoding Homer proteins and their interacting proteins.

Career Highlights

Throughout his career, Paul R Brakeman has worked with prestigious institutions, including Johns Hopkins University. His research has contributed to advancements in understanding synaptic functions and their implications for neurological disorders.

Collaborations

Brakeman has collaborated with esteemed colleagues such as Paul F Worley and Jian Cheng Tu. These collaborations have further enriched his research and expanded the impact of his inventions.

Conclusion

Paul R Brakeman's innovative work in the field of synaptic activation proteins has led to significant advancements in neuroscience. His contributions continue to influence research and understanding in this critical area of study.