Location History:
- Grangemouth, GB (2009)
- Stirlingshire, GB (2011)
Company Filing History:
Years Active: 2009-2011
Title: Paul McCormac: Innovator in Oligonucleotide Synthesis
Introduction
Paul McCormac is a notable inventor based in Grangemouth, GB. He has made significant contributions to the field of biotechnology, particularly in the synthesis and purification of oligonucleotides. With a total of three patents to his name, McCormac's work has advanced the methodologies used in this critical area of research.
Latest Patents
One of McCormac's latest patents is titled "Process for purifying oligonucleotide synthons." This innovative process involves subjecting an organic solution containing an oligonucleotide synthon and lower molecular weight impurities to nanofiltration. The result is an increased ratio of the oligonucleotide synthon to impurities after the filtration process. The preferred oligonucleotide synthons in this patent are nucleoside phosphoramidites or nucleoside H-phosphonates, utilizing a polyimide membrane with a molecular weight cut-off of 400.
Another significant patent by McCormac is "Process for the preparation of oligonucleotides." This process describes the synthesis of an oligonucleotide assembled on a swellable solid support using the phosphoramidite approach. Notably, the activator used in this process is not tetrazole or its substituted variants. Instead, preferred activators include pyridinium, imidazolinium, and benzimidazolinium salts, among others. The swellable solid supports mentioned in this patent comprise functionalized polystyrene, partially hydrolyzed polyvinyl acetate, or poly(acrylamide).
Career Highlights
Paul McCormac is currently associated with Avecia Biotechnology, Inc., where he continues to innovate in the field of biotechnology. His work has been instrumental in enhancing the efficiency and effectiveness of oligonucleotide synthesis and purification processes.
Collaborations
Throughout his career, McCormac has collaborated with notable colleagues, including David John Moody and Donald Alfred Wellings. These collaborations have contributed to the advancement of research and development in their shared field of expertise.
Conclusion
Paul McCormac's contributions to the field of oligonucleotide synthesis and purification are noteworthy. His innovative patents reflect a commitment to advancing biotechnology, making significant strides in the efficiency of oligonucleotide production. His work continues to influence the industry positively.