The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2011
Filed:
Dec. 16, 2003
Andrew Timothy Boam, London, GB;
Andrew Guy Livingston, London, GB;
Dinesh Nair, London, GB;
Paul Mccormac, Stirlingshire, GB;
Stephen Hargreaves, Stirlingshire, GB;
Andrew Timothy Boam, London, GB;
Andrew Guy Livingston, London, GB;
Dinesh Nair, London, GB;
Paul McCormac, Stirlingshire, GB;
Stephen Hargreaves, Stirlingshire, GB;
Avecia Biotechnology, Inc., Milford, MA (US);
Abstract
A process for the purification of an oligonucleotide synthon is provided. The process comprises subjecting an organic solution comprising an oligonucleotide synthon and lower molecular weight impurities to nanofiltration whereby the ratio of an oligonucleotide synthon to lower molecular weight impurities in the solution is increased after the nanofiltration. Preferably, the oligonucleotide synthon is a nucleoside phosphoramidite or nucleoside H-phosphonate. The nanofiltration membrane is preferably a polyimide membrane having a molecular weight cut off of 400.