Paul Kaplan

Title: Paul Kaplan: Innovator in Genetic Analysis

Introduction

Paul Kaplan is a notable inventor based in Campbell, CA (US). He has made significant contributions to the field of genetic analysis, holding 2 patents that focus on innovative methods for determining genotypes at polymorphic loci. His work has implications for both individual genetic testing and population genetics.

Latest Patents

Kaplan's latest patents include a method for identifying alleles that employs amplification of a region of DNA using primers containing tags. This method allows for the hybridization of the products to one or more probes on a solid support. The genotype or ratio of alleles is identified from the pattern of hybridization, and the method can also be used to determine the frequency of different alleles in a population. Another patent focuses on allele detection using primer extension with sequence-coded identity tags. This method also amplifies a region of DNA and labels allele-specific extension primers containing tags, allowing for hybridization to an array of probes. The genotype is identified from the pattern of hybridization, and this method can similarly determine the frequency of different alleles in a population.

Career Highlights

Paul Kaplan is currently associated with Affymetrix, Inc., a company known for its advancements in genetic analysis technologies. His work at Affymetrix has positioned him as a key player in the development of innovative genetic testing methods.

Collaborations

Kaplan has collaborated with notable colleagues, including Xiaohua C Huang and Tom Ryder. These collaborations have further enhanced the impact of his work in the field of genetics.

Conclusion

Paul Kaplan's contributions to genetic analysis through his innovative patents and work at Affymetrix, Inc. highlight his role as a significant inventor in the field. His methods for determining genotypes have the potential to advance both individual and population-level genetic research.