Paul C Guley

Title: The Innovations of Paul C. Guley: A Remarkable Inventor from Plattsburgh, NY

Introduction: Paul C. Guley is an accomplished inventor based in Plattsburgh, New York, known for his contributions to the pharmaceutical industry. With a total of eight patents to his name, Guley's innovations have significantly impacted how medications are formulated and administered.

Latest Patents: Among his notable inventions, two patents stand out: the "Preparation of Propranolol Hydrochloride Macrocrystals" and "Rapid Releasing Triamterene Containing Gelatin Capsule Dosage Forms." The first patent describes a process for obtaining high yields of propranolol hydrochloride, characterized by a particle size ranging from 420 to 1200 microns. This process involves recrystallizing propranolol hydrochloride using a mixture of n-propanol and heptane as a solvent. The macrocrystals produced are integral in developing sustained-release capsule and tablet pharmaceutical dosages. The second patent introduces a gelatin capsule dosage form that contains triamterene, achieving rapid dissolution of the active ingredient. This innovative formulation incorporates methylcellulose as a binder, along with disintegrants like low doses of a surfactant or a carbonate salt.

Career Highlights: Paul C. Guley has made significant strides in his career at American Home Products Corporation, where he has harnessed his expertise to develop groundbreaking pharmaceutical innovations. His work has enhanced the efficacy and reliability of medications, showcasing his commitment to advancing healthcare.

Collaborations: Throughout his career, Guley has collaborated with esteemed colleagues such as Richard J. DeNeale and George Milosovich. These partnerships have fostered an environment of creativity and technical expertise, leading to successful patent applications and further developments in drug delivery systems.

Conclusion: Paul C. Guley's contributions to the field of pharmaceuticals through his patents exemplify the spirit of innovation. His ongoing work in developing effective drug formulations not only advances medical sciences but also plays a crucial role in patient care. As an inventor, Guley’s efforts highlight the importance of research and collaboration in the pursuit of better health outcomes.