American Home Products Corporation

Paul C Guley

Richard J DeNeale

George Milosovich

James S Farina

There is described a process for the preparation of high yields of propranolol hydrochloride having a particle size within the range of 420 to 1200 microns wherein the propanolol hydrochloride is recrystallized from, as a solvent, a mixture of n-propanol and heptane. The propranolol hydrochloride macrocrystals are useful themselves in capsule pharmaceutical dosage forms and when coated with a sustained release coating composition, are useful in the manufacture of sustained action capsule and tablet pharmaceutical dosage.

Preparation of propranolol hydrochloride macrocrystals

A gelatin capsule dosage form containing triamterene, 2,4,7-triamino-6-phenylpteridine, which results in rapid dissolution of the active ingredient. The dosage form comprises the pharmaceutical binder methylcellulose in combination with low doses of a surfactant or a carbonate salt as disintegrants.

Rapid releasing triamterene containing gelatin capsule dosage forms for

Novel sustained release compositions comprising a core containing a drug, a seal coating surrounding the core and a sugar coating surround the seal coated core are disclosed.

Sustained release pharmaceutical compositions

Novel sustained release compositions comprising a core containing a drug, a seal coating surrounding the core and a sugar coating surrounding the seal coated core are disclosed.

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Plattsburgh, NY, United States of America

Paul C Guley