Company Filing History:
2 out of 2 
1 out of 3 
1 out of 1,415 
Years Active: 1998-2001
Title: Innovations and Contributions of Inventor Paul Brian
Introduction
Paul Brian is a notable inventor based in San Diego, California. He has made significant contributions to the field of drug discovery and biotechnology, holding a total of four patents. His work focuses on generating molecular diversity and enhancing antibiotic production through innovative methods.
Latest Patents
One of Paul Brian's latest patents is titled "Methods for generating and screening novel metabolic pathways." This invention relates to a novel drug discovery system that generates molecular diversity. The system employs methods for subjecting genetic materials from various species to homologous or homeologous recombination, creating novel genes and metabolic pathways. The recombined genetic materials are then cloned to form combinatorial gene expression libraries. Additionally, he has developed methods for screening these libraries for novel activities and compounds. Another significant patent is "Method, DNA and bacteria for hyperproduction of an antibiotic." This patent describes a recombinant Streptomyces species that exhibits hyperproduction of antibiotics, particularly actinorhodin and undecylprodigiosin. The invention involves interrupting the absA homologous locus of chromosomal DNA, which is believed to encode a histidine kinase and a response regulator.
Career Highlights
Throughout his career, Paul Brian has worked with various companies, including Chromaxome Corporation and Terragen Discovery Inc. His innovative approaches have contributed to advancements in biotechnology and pharmaceutical research.
Collaborations
Paul has collaborated with notable individuals in his field, including Todd C. Peterson and Lyndon M. Foster. These collaborations have further enhanced his research and development efforts.
Conclusion
Paul Brian's contributions to the field of drug discovery and biotechnology are noteworthy. His innovative patents and collaborations reflect his commitment to advancing scientific knowledge and improving healthcare solutions.