The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 02, 1999
Filed:
Feb. 06, 1997
Applicant:
Inventors:
Wendy C Champness, East Lansing, MI (US);
Paul Brian, San Diego, CA (US);
Todd B Anderson, East Lansing, MI (US);
Assignee:
Board of Trustees operating Michigan State University, East Lansing, MI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; C07H / ;
U.S. Cl.
CPC ...
4351723 ; 43525235 ; 536 232 ; 536 237 ;
Abstract
A recombinant Streptomyces sp. which exhibits hyperproduction of an antibiotic, particularly actinorhodin and undecylprodigiosin, as a result of interruption of the absA homologous locus of chromosomal DNA (SEQ ID NO:1) is described. The gene is thought to encode a histidine kinase and a response regulator. The preferred bacterium is Streptomyces coelicolor. It is preferred to interrupt the absA1 gene with ermE DNA.