Paul B Card

Title: Paul B Card: Innovator in NMR Detection of Foreign PAS Domain Ligands

Introduction

Paul B Card is a notable inventor based in Dallas, TX (US). He has made significant contributions to the field of molecular biology, particularly in the area of NMR detection. His innovative work focuses on the specific binding of foreign core ligands to PAS domains, which are crucial in various biological processes.

Latest Patents

Paul B Card holds a patent for "NMR detection of foreign PAS domain ligands." This patent describes a method for determining the specific binding of a foreign core ligand to a PAS domain. The PAS domain is predetermined and prefolded in its native state, featuring a hydrophobic core that lacks an NMR-apparent a priori formed ligand cavity. The method utilizes NMR spectra of the PAS domain in both the presence and absence of a foreign ligand bound within the hydrophobic core. The functional surface binding specificity of the PAS domain can be altered by introducing a foreign ligand into the hydrophobic core and detecting changes in its binding specificity.

Career Highlights

Paul B Card is affiliated with the University of Texas System, where he continues to advance research in his field. His work has garnered attention for its innovative approach to understanding protein-ligand interactions.

Collaborations

Throughout his career, Paul has collaborated with esteemed colleagues, including Kevin H Gardner and Carlos A Amezcua. These collaborations have further enriched his research and contributed to advancements in molecular biology.

Conclusion

Paul B Card is a distinguished inventor whose work in NMR detection of foreign PAS domain ligands has made a significant impact in the field of molecular biology. His innovative methods and collaborations continue to push the boundaries of scientific research.