The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 12, 2010
Filed:
Oct. 01, 2003
Kevin H. Gardner, Dallas, TX (US);
Carlos A. Amezcua, Dallas, TX (US);
Paulus J. A. Erbel, Dallas, TX (US);
Paul B. Card, Dallas, TX (US);
Kevin H. Gardner, Dallas, TX (US);
Carlos A. Amezcua, Dallas, TX (US);
Paulus J. A. Erbel, Dallas, TX (US);
Paul B. Card, Dallas, TX (US);
Board of Regents, The University of Texas System, Austin, TX (US);
Abstract
Specific binding of a foreign core ligand to a PAS domain, wherein the PAS domain is predetermined, prefolded in its native state, and comprises a hydrophobic core that has no NMR-apparent a priori formed ligand cavity, is determined using NMR spectra of the PAS domain in the presence and absence of a foreign ligand bound within the hydrophobic core. A functional surface binding specificity of a PAS domain is changed by (a) introducing into the hydrophobic core of the PAS domain a foreign ligand of the PAS domain; and (b) detecting a change in the functional surface binding specificity of the PAS domain.