Patrick Ho

Title: The Innovative Contributions of Patrick Ho

Introduction

Patrick Ho is a notable inventor based in Fremont, CA, who has made significant contributions to the field of biotechnology. With a total of 3 patents to his name, he has focused on developing advanced methods and compositions that enhance targeted therapies.

Latest Patents

One of his latest patents is titled "Cytotoxic molecules responsive to intracellular ligands for selective T cell mediated killing." This invention provides compositions and methods for the cell-mediated targeted killing of diseased cells based on the presence of an intracellular antigen, rather than a surface-bound marker. The targeting cells are modified to express a cytotoxic protein that is delivered into a targeted cell, and after delivery, it is selectively activated by the presence of a cytoplasmic protein of interest. In one embodiment of the invention, the cytotoxic molecule is a Granzyme B (GrB) polypeptide. The compositions of this invention modify GrB to render its cytotoxic enzymatic functions inactive until the presence of an intracellular antigen unlocks the GrB molecule to enable enzymatic activities.

Another significant patent is a "Method for clustering signals in spectra." This method involves processing spectra by obtaining a plurality of spectra, each comprising a signal that includes a signal strength as a function of time-of-flight, mass-to-charge ratio, or a value derived from these measurements. The method then forms a signal cluster by clustering signals from the plurality of spectra that are within a defined window based on an expected signal width value.

Career Highlights

Throughout his career, Patrick Ho has worked with prominent companies in the biotechnology sector, including Ciphergen Biosystems, Inc. and Bio-Rad Laboratories, Inc. His work has contributed to advancements in the understanding and application of biotechnological innovations.

Collaborations

Patrick has collaborated with notable professionals in his field, including Edward J. Gavin and Cynthia Y. Enderwick. These collaborations have further enriched his research and development efforts.

Conclusion

Patrick Ho's innovative work in biotechnology, particularly in targeted therapies and signal processing, showcases his commitment to advancing medical science. His contributions continue to influence the field and pave the way for future innovations.