Patrick Fier

Title: Patrick Fier: Innovator in Fluorination Chemistry

Introduction

Patrick Fier is a notable inventor based in Berkeley, CA. He has made significant contributions to the field of chemistry, particularly in the area of fluorination reactions. With a total of 5 patents to his name, Fier's work has implications for pharmaceuticals and agrochemicals.

Latest Patents

One of his latest patents is a one-component reagent for the fluoroalkylation reaction. This composition consists essentially of copper, a fluoroalkyl group, and a ligand comprising at least one group-V donor. The molar ratio of copper to the fluoroalkyl group is approximately 1. Another significant patent involves the C-H fluorination of heterocycles with silver (II) fluoride. This invention provides compositions and methods for the selective C—H fluorination of nitrogen-containing heteroarenes with AgF, which has previously been considered too reactive for practical, selective C—H fluorination. The present invention offers a mild and general method for the C—H fluorination of nitrogen-containing heteroarene compounds to 2-fluoro-heteroarenes with commercially available AgF. These reactions can occur at ambient temperature within one hour and exhibit exclusive selectivity for fluorination at the 2-position.

Career Highlights

Fier has worked at prestigious institutions, including the University of California and the University of Illinois. His research has focused on developing innovative methods for chemical reactions that are both efficient and practical.

Collaborations

Some of his notable coworkers include John F. Hartwig and Hiroyuki Morimoto. Their collaborative efforts have contributed to advancements in the field of chemistry.

Conclusion

Patrick Fier's innovative work in fluorination chemistry has led to significant advancements in the field. His patents reflect a commitment to improving chemical processes that are essential for various applications.