Company Filing History:
3 out of 1,745 
3 out of 5,094 
2 out of 18 Years Active: 2017-2021
Title: Patrick Collombat: Innovator in Diabetes Treatment
Introduction
Patrick Collombat is a notable inventor based in Nice, France, recognized for his contributions to diabetes research. He holds a total of 3 patents that focus on innovative methods for treating hyperglycemia and improving diabetes therapies. His work has significant implications for the medical field, particularly in the management of diabetes.
Latest Patents
Collombat's latest patents include groundbreaking inventions such as GFI1 inhibitors for the treatment of hyperglycemia. This invention relates to methods and pharmaceutical compositions that are useful for managing hyperglycemia. Through extensive analyses, it was demonstrated that Gfi1 is expressed in pancreatic acinar cells from the early stages of pancreatic embryonic development. The research revealed that Gfi1 mRNA levels remain stable throughout embryonic development but significantly increase during the initial days of life. In experiments with conditional mutant mice subjected to a high-fat diet for five months, it was observed that while control mice developed severe hyperglycemia, the mutant mice maintained normoglycemia throughout the study. This finding suggests a potential method for treating hyperglycemia by administering a therapeutically effective amount of a Gfi1 inhibitor.
Another significant patent involves alpha-cell regeneration combined with the conversion to beta cells. This invention outlines methods for generating beta cells from alpha cells by treating them with GABA or a GABA receptor agonist, along with a monoclonal glucagon neutralizing antibody or other compounds that regulate alpha cell mass. This innovative approach aims to enhance diabetes therapy.
Career Highlights
Throughout his career, Patrick Collombat has worked with esteemed institutions such as the Institut National de la Santé et de la Recherche Médicale and the Centre National de la Recherche Scientifique. His research has contributed to advancements in diabetes treatment and has positioned him as a key figure in the field.
Collaborations
Collombat has collaborated with notable colleagues, including Keith Al-Hasani and Monica Courtney, further enriching his research endeavors and expanding the impact of his work.
Conclusion
Patrick Collombat's innovative patents and research contributions have made a significant impact on diabetes treatment. His work continues to inspire advancements in medical science and offers hope for improved therapies for individuals affected by hyperglycemia.